The Making and Knowing Project, founded in 2014 by Pamela H. Smith, and involving hundreds of collaborators, is a research and pedagogical initiative in the Center for Science and Society at Columbia University. The Project explores the intersections between historical craft making and scientific knowing. Drawing on techniques from both laboratory and archival research as well as studio practice and the digital humanities, the Making and Knowing Project aims to cross the science/humanities divide. The creation of Secrets of Craft and Nature in Renaissance France has been the Project’s primary endeavor since 2014. This goal has shaped the Project’s methodology of fusing pedagogy with research, using a focused research object (Ms. Fr. 640) to teach historical, hands-on, and digital research methods while generating research outputs.